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Devesh Bhimsaria
Assistant Professor
devesh.bhimsaria[at]bt.iitr.ac.in
F9, BSBE, IIT Roorkee
+91-1332-285011
https://scholar.google.com/citations?user=9qpALAEAAAAJ&hl=en
Research Interests

Biosketch
Educational Details
Professional Background

Research
Projects
Publications
Patents
Books
Collaborations

Honours and Awards
Honors
Memberships

Teaching Engagements
Teaching Engagements

Students
Supervisions
Associate Scholars

Miscellaneous
Events
Visits
Administrative Positions
Miscellaneous
Research Interests
Computational Biology, Bioinformatics and Deep Learning, Computational approaches for DNA-protein binding prediction, Nano-material based electrochemical biosensor development for cervical cancer detection, Burn wound severity detection via deep learning techniques
BioSketch
Educational Details
University of Wisconsin–Madison, United States Of America
2014
Master of Science (M.S.), Department of Electrical & Computer Engineering
University of Wisconsin–Madison, United States Of America
2016
Ph.D., Department of Electrical & Computer Engineering
Indian Institute of Technology, Roorkee, India
2010
Integrated Dual Degree (B.Tech. + M.Tech.), Department of Electronics & Communication Engineering
Professional Background
Research Scientist
01 Aug 2018 - 29 May 2022
Bio Informaticals
Postdoctoral Fellow
01 Jan 2017 - 31 Jul 2018
University of Wisconsin–Madison
Associate Applications Developer
01 Jul 2010 - 10 Mar 2011
Oracle India Pvt. Limited
Research
Projects
TOPIC START DATE FIELD DESCRIPTION FINANCIAL OUTLAY FUNDING AGENCY OTHER OFFICERS
lnvestigating DNA Recognition by proteins and Modeling to predict Binding 02 Mar 2023 Computational Biology 20,00,000 INR IIT Roorkee, IIT Roorkee, India
Machine learning model of specificity anchors and clustered binding sites tounravel DNA binding of proteins and drugs 18 Jan 2024 Bioinformatics 24,75,000 INR SERB, IIT Roorkee, India




Publications
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis
2025
A Arabzade, et al. | Nature
Journal: Nature Cell Biology Pages: 1496–1509 , Volumes: 27 ,
Strategic design of a multi-tier database for class A β-lactamase BlaC variants of M. tuberculosis: advancing the fight against antibacterial resistance
2025
KC Ananth Kumar, Adwaita Nair, Shreya Sharma, Deepika Singh, Shivam Yadav, Devesh Bhimsaria, Sebanti Gupta, Saugata Hazra | The Journal of Antibiotics
Journal: The Journal of Antibiotics
Collaborations
DNA binding polyamide for drug design
St Jude's Children's hospital, Memphis, United States Of America
Protein-DNA Binding prediction algorithm design
University of Wisconsin Madison, Madison, United States Of America
DNA shape involvement in protein binding prediction
BITS Dubai, Dubai, United Arab Emirates
SNP responsible for congenital heart disorders
University of Puerto-Rico, Puerto-Rico, Puerto Rico
Honors And Awards
Honors
Department of Electrical and Computer Engineering, University of Wisconsin–Madison
2017
Harold A. Peterson Distinguished Dissertation Award for Ph.D. dissertation
University of Wisconsin–Madison
2016
Academic achievement award for securing 4.0/4.0 GPA in M.S. + Ph.D.
Indian Institute of Technology, Roorkee
2010
Silver Medal for securing highest GPA in Integrated Dual Degree program
University of Wisconsin–Madison
2008
Khorana Scholarship
Teaching Engagements
Teaching Engagements
Computational Biology ( BEC-303 )
Autumn
Bioinformatics ( DA-424 )
Autumn
Computational Biology ( BEL-514 )
Spring
Data Science ( DAI-101 )
Spring
Essentials of Biosciences and Mathematics ( BEC-511 )
Autumn
Miscellaneous
Visits
IISER, Bhopal, Madhya Pradesh, India
2024-03-11
Conference: 16th Young Investigators' Meeting (YIM)
Ayodhya, Ayodhya, Uttar Pradesh, India
2025-02-13
National Academy of Burns India Conference (NABICON)
Regional Centre for Biotechnology, Faridabad, Haryana, India
2025-02-19
Computational Biology Conference (CBC)
Administrative Positions
Department Faculty Search Committee (DFSC) Convenor
01 Jan 2023 - 31 Dec 2023
IIT Roorkee, Roorkee, Uttarakhand, India
OC New Building BSBE
01 Jul 2022 - Present
IIT Roorkee, Roorkee, Uttarakhand, India
Chairperson
21 Aug 2025 - Present
Committee for Campus Fauna, Roorkee, Uttarakhand, India
Research publications:

(*-equal contribution, †-Corresponding Author)

1.       Kumar K.C.A., Nair A., Sharma S., Singh D., Yadav S., Bhimsaria D., Gupta S., and Hazra S.  Strategic design of a multi-tier database for class A β-lactamase BlaC variants of M. tuberculosis: advancing the fight against antibacterial resistance. The Journal of Antibiotics (2025). https://doi.org/10.1038/s41429-025-00862-3. (Impact factor: 2.1)

2.       Arabzade A., Shirnekhi H.K., Varadharajan S. et al. Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis. Nature Cell Biology (2025) 27, 1496–1509 (2025). https://doi.org/10.1038/s41556-025-01745-3. (Impact factor: 21.3)

3.       Bhimsaria D.*†, Rodríguez-Martínez J.A.*, Méndez J., Ghoshdastidar D., Varadarajan A., Bansal M., Daniels D.L., Ramanathan P., and Ansari A.Z. (2023) Hidden Modes of DNA Binding by Human Nuclear Receptors. Nature Communications 14, 4179. (Impact factor: 17.69)

4.       Jana I.D., Bhattacharya P., Mayilsamy K., Banerjee S., Bhattacharje G., Das S., Aditya S., Ghosh A., McGill A.R., Srikrishnan S., Das A.K., Basak A., Mohapatra S.S., Chandran B., Bhimsaria D., Mohapatra S., Roy A., Mondal A. (2022) Targeting an evolutionarily conserved “ELL” motif in spike protein to identify a small molecule fusion inhibitor against SARS-CoV-2. PNAS nexus, Volume 1, Issue 5, November 2022, pgac198.

5.       Finn P.B.*, Bhimsaria D.*, Ali A., Eguchi A., Ansari A.Z., and Dervan P.B. (2020) Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome. PLoS ONE 15(12): e0243905. (Impact factor: 3.75)

6.       Liu X., Gupta S.T.P., Bhimsaria D., Reed J.L., Rodríguez-Martínez J.A., Ansari A.Z., and Raman S. (2019) De novo design of programmable inducible promoters. Nucleic Acids Research, 47, 10452–10463. (Impact factor: 19.16)

7.       Yella V.R.*, Bhimsaria D.*, Ghoshdastidar D., Rodríguez-Martínez J.A., Ansari A.Z., and Bansal M. (2018) Flexibility and structure of flanking DNA impact transcription factor affinity for its core motif. Nucleic Acids Research, 46, 11883–11897. (Impact factor: 19.16)

8.       Bhimsaria D., Rodríguez-Martínez J.A., Pan J., Roston D., Korkmaz E.N., Cui Q., Ramanathan P., and Ansari A.Z. (2018) Specificity landscapes unmask submaximal binding site preferences of transcription factors. Proceedings of the National Academy of Sciences of the United States of America, 115, E10586–E10595. (Impact factor: 12.78)

9.       Rodríguez-Martínez J.A.*, Reinke A.W.*, Bhimsaria D.*, Keating A.E., and Ansari A.Z. (2017) Combinatorial bZIP dimers define complex DNA-binding specificity landscapes. eLife 6, e19272. (Impact factor: 8.71)

10.    Eguchi A., Wleklinski M.J., Spurgat M.C., Heiderscheit E.A., Kropornicka A.S., Vu C.K., Bhimsaria D., Swanson S.A., Stewart R.M., Ramanathan P., Kamp T.J., Slukvin I.I., Thomson J.A., Dutton J.R., and Ansari A.Z. (2016) Reprogramming cell fate with a genome-scale library of artificial transcription factors. Proceedings of the National Academy of Sciences of the United States of America, 113 (51) E8257-E8266. (Impact factor: 12.78)

11.    Erwin G.S., Grieshop M.P.*, Bhimsaria D.*, Do T.J., Rodríguez-Martínez J.A., Mehta C., Khanna K., Swanson S.A., Stewart R., Thomson J.A., Ramanathan P., and Ansari A.Z. (2016) Synthetic genome readers target clustered binding sites across diverse chromatin states. Proceedings of the National Academy of Sciences of the United States of America, 113 (47) E7418-E7427. (Impact factor: 12.78)

12.    Erwin G.S., Grieshop M.P., Bhimsaria D., Eguchi A., Rodríguez-Martínez J.A., and Ansari A.Z. (2016) Genome-wide mapping of drug-DNA interactions in cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin). Journal of Visualized Experiments, (107), e53510. (Impact factor: 1.4)

13.    Erwin G.S., Bhimsaria D., Eguchi A., and Ansari A.Z. (2014) Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites. Angewandte Chemie (International Ed. in English), 53(38), 1–6. (Impact factor: 16.82)

14.    Meyer P., Cokelaer T., Chandran D., Kim K.H., Loh P.R., Tucker G., Lipson M., Berger B., Kreutz C., Raue A., Steiert B., Timmer J., Bilal E., DREAM 6&7 Parameter Estimation consortium, Sauro H.M., Stolovitzky G., and Saez-Rodriguez J. (2014) Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach. BioMed Central Systems Biology 8(1), 13. (Impact factor: 2.05)

15.    Campbell Z.T., Bhimsaria D., Valley C.T., Rodriguez-Martinez J.A., Menichelli E., Williamson J.R., Ansari A.Z., and Wickens M. (2012) Cooperativity in RNA-Protein Interactions: Global Analysis of RNA Binding Specificity. Cell Reports, 1(5), 570–581. (Impact factor: 9.99)

16.    Tietjen J.R., Donato L.J., Bhimsaria D., and Ansari A.Z. (2011) Sequence-specificity and energy landscapes of DNA-binding molecules. Methods in Enzymology, 497, 3–30. (Impact factor: 1.68)

17.    Carlson C.D., Warren C.L., Hauschild K.E., Ozers M.S., Qadir N., Bhimsaria D., Lee Y, Cerrina F, and Ansari A.Z. (2010) Specificity landscapes of DNA binding molecules elucidate biological function. Proceedings of the National Academy of Sciences of the United States of America, 107(10), 4544–9. (Impact factor: 12.78)

18.    Singh D., Srivastava V., Pandey B., and Bhimsaria D. (2009) Application of neural network with error correlation and time evolution for retrieval of soil moisture and other vegetation variables. Progress In Electromagnetics Research, 15(15), 245–465. (Impact factor: 2.95)

Selected Conferences:

Computational Biology Conference (CBC) at Regional Centre for Biotechnology, Faridabad, India (Feb19-21, 2025)

National Academy of Burns India Conference (NABICON) in Ayodhya, India (Feb. 13-15, 2025)

16th Young Investigators' Meeting (YIM) in Bhopal, India (Mar. 11-15, 2024)